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299 Ķ 2020-6-28 13:39 |ϵͳ:Ľ| ڳ, ҩ, ҩ, ϵͳ, Ѫ˨֢

Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy

Min Su#, Qixuan Dai#, Chuan Chen, Yun Zeng, Chengchao Chu*, Gang Liu*
Nano‑Micro Lett.(2020) 12:96
https://doi.org/10.1007/s40820-020-00434-0


1. ҩѪ˨֢Ϻоչ
2. Ѫ˨־׷̽ڳʵѪ˨֢ϡ
3. ҩϵͳΪѪ˨ƵЧʽҾнϺõٴתԡ
о
Ѫ˨γѪܼйأļз硣һȫԵĽ⣬ҲǵҪ֮һǣĿǰѪ˨γɵٴϾڼڣӶƴխṩЧơ⣬ٴõ˨ҩͨ˥ڶ̣ҿܻӦҪ֯Ѫ⡣ҩڼеƣҩѪ˨γɵϺҲȡ˽ϺõЧԱĹ㷺ע
ݼ
ŴѧսڿڱܽҩѪ˨ϺƵ½չչܷΪ͵ϵ1)ʹáϳ־ϵ2)ʹ̽Ѫ˨ϣ3)ҩϵͳӦ˨ƣ4)Ѫ˨΢Ӧҩϵͳ5)׸ҩϵͳ6)ⲿϵչҩٴѪ˨γϺҪԼչķ
ͼĵ
ҩѪ˨еӦ
1.1 
򵥡١ϮԵŵ㷺оø(ELISA)ӦҽԺϡ׿Ϊѱڼ⼲־ȻѪ˨ص־ѪУѪҺû־޷ֱӼ⵽Щ־ͨưϳ־׸עѪ˨лͷšϳ־ͨ˵ҺСһռҺͿʵ֡ϳ־IJԡ
Bhatia׳(NWs)ΪѪ˨Ӧ(TAP)-е(ͼ1-a)Ʊ׸ϲ϶ѪøѡԣѪøͷŶƬΡռҺELISAֽʵֶƬεIJⶨϵҪϳʱĴл޷ʵѪ˨ĿٲⶨڽһоУBhatiaȽTAPżҶ֧(PEG-T1E)棬Ʊһ֡ϳ־׸ϲ(ͼ1-b)PEG-T1EˮֱԼΪ8 nmԴٽ׸ϲϵƤעѪ⣬Ƥעϳ3 h󣬾ͿҺвԵϳ־ӶʵѪ˨Ŀϡ


ͼ1. ڡϳ־Ѫ˨֢ϡ

1.2 ڳ

ĿǰѾڳ񷽷Ѫ˨ϣг(US)Ź(MRI)ӷϲ(PET)Ѫ˨ٴеõ㷺ӦáȻӰѧѪ˨Ѫ˨γɵϺʵ֪֡ѧԣάסѪС塢XIIIȣѪ˨γءѪ˨γ־ĿӻִӳĻһоڼľ׼DZҪġ

̽õijܣаӵ׿Ӱ׼ȷѪ˨2017꣬CuiƱ˶Ƕ-3,4,9,10-Ȼǰ(PDI)װл뵼׿(~40 nm)ӾĹ(PA)(ͼ2)һκ󣬽cRGD-PDI׿ע䵽ڣͨPAIоͼ2ʾcRGD-PDI׿ܹʶѪ˨ʾõijܡ⣬cRGD-PDI׿Ѫ˨Ѫ˨Ѫ˨̡ܽ

׽ṹڳѳΪоķڳҪҪأ1)̽ӦͻijܻѪ˨γɵ΢ʾ2)ʹӰнϳѭʱ䡢Ѫ˨Ժʵﰲȫԡ

ͼ2.cRGD-PDI׿ƱѪ˨֢PAIеӦá

II ҩѪ˨еӦ

2.1 ˨ҩϵͳ

ҩϵͳҲӦ˨УѾ֤ڵ˨Ч֬ΣװҩΪ˨ѡ塣⣬ʹ⼤Ѫ˨λʾЧͷţ֬(ELIP)֬ʵӲǣ˷飬װ֯øԭ(rt-PA)׸ϲעںڱεݸѪУֲUSʹrt-PAͷŲջԣʵ˨Ч

Colasuonnoþ-ǻṲ(PLGA);Ҷ(PEG)Ʊһģϸ״׽ṹصĽṹԷֹҩڻۣԳѪ֯øԭ(tPA)ڲϱ档׸ϲ϶صĽṹʹڳѭõ˨Чʡ

˨ҩ⣬ҩҲӦ˨ơΪˣһˮ(pDNA)ͨѪXa(FXa)ӡ⣬RGDyCPEGھ״ۺ(PAMAM)Ͻ˸ԡȻpDNAPAMAM档ñεRGDyCpDNA԰Ѫ˨λѪ˨УԱˮںϵףҸõͬʱRGDyCյѪ˨γɵĵڶΰЧӦ

о룬л޻׽ṹӦѪ˨СЩϵӦأ1)׽ṹòСͱӦҩѪи׽ṹӦеﶾԣ2)ҩӦþнϺõȶԣѪҺ˨ҩﲻ΢ͷţ3)๦׿ӦܹʵӰѧָ

2.2 Ѫ˨΢Ӧҩϵͳ

ڼ΢ҩᆱ׼ͷŴӶٽ֯еҩͷŵĵͲҲ㷺оңͷŲԷdzʺ˨ҩͷţԼ˨ĸáѪ˨γɹУ(H2O2)ѪСзҪãܹ̼ѪСۼˣH2O2ǻѪСһҪ־H2O2ƼֳѪСѪС壬ӶʾԿѪ˨Ч

LeeƱH2O2ӦάװͿѪ˨׸(FTIAN)(ͼ3)УFTIAN溬άΪеĶġӦH2O2Ρӫ̽IR820۽ϾۺԼװ˨(tirofiban)ںˡѪ˨߿УH2O2ãFTIANԽۣȻͷtirofibanͬʱH2O2µ-(TNF-)ͿCD40(sCD40L)ˣFTIANʾͿãڿѪ˨γɺ˨

ͼ3.H2O2Ӧ˨ơ

2.3 ׸ҩϵͳ

л޻׽ṹҲӦҩϵͳСУϸĤԴϸҾԸߡѪҺѭʱ䳤׻򹤳̸ص㣬㷺оѪ˨γУҪĹѪСľۼͻˣѪСĤоۼѪ˨߿еѪСĤ(PM)ҩҲӦѪ˨С2016꣬GuPM׿tPAƱ˷˨ͼ4ʾPM԰ھۺں˵ı棬ƱtPA-PM-NPԼΪ127 nmңע󣬸׸ܹܺõľۼڷѪ˨С⣬ھϳʱѭtPAȻܹøԡtPA-PM-NPע䵽Ѫ˨ģͺάԭӫǿԽ͡

ͼ4. PM˨ơ

2.4 ⲿҩϵ

ʹ˨ҩ⣬ӦûеáƺͻȽ˨ơڳİ£Ѫ˨λмԼٶ֯𺦡磬Zhong˽ȫ̼(PFH)PLGA׿УFe3O4׿صPLGA(ͼ5)һΰCREKAĺ󹹽˶๦ת˨ҩö๦׸ﻹMRPAUSӰܣӶʵֶģָ̬µѪ˨γɵϡڰĵ£׸ԸѪ˨߿λáȻѪ˨ͨǿȾ۽US(LIFU)Ѫ龭ѪϸѪά׽Աκ˨Ч

ͼ6.ģ̬HIFUѪ˨ơ

III ۺչ

ĿǰҩѪ˨ϺƷѱһЩѾȡ˽ϺõЧܽѪ˨ϺϵҪ߱

1)ȣҩѪ˨λĻٴƵǰᡣðĵȶҩξҪ塣ͬʱҩ̬СͱˮԵҲӰҩѪ˨еĸ

2)Σ˨ҩ֯λѪѪܼ𺦡Ѫ˨΢//żĸҩϵͳʵҩֻѪ˨λͷŶ֯ڽй©ĿɿͷţԽ͸á

3)ʵʱ񲻽ԽѪ˨߿ֿ֯ṩѪ˨ϸϢˣӰµǸԻƵĹؼء

߼

ɳ

ͨѶ

Ŵѧ оԱ

Ҫо

ҪҽѧӰ̽롢һ廯оΧش󼲲ѪܶģͿչһϵло

Ҫоɹ

Angewandte Chemie International EditionAdvanced Materials Advanced Functional MaterialsAdvanced ScienceTheranosticsȸӰѧڿԵһ߻ͨѶ߷10 ƪٻ񸣽ʡ㲩ʿҵģйҽѧѧ㲩ʿġȨйר6ѧĿʿ

Email: chuchengchao0225@163.com

ͨѶ

Ŵѧ Ƹ

Ҫо

Ҫ·Ӱ̽롢ҽø߷ӡҩ/ϵȹ

Ҫоɹ

Ȼѧܳߡѡ˼ƻμ˲š˲šʡ֧ƻƼ˲ŵȡΪͨѶ/ͨѶPNASNat CommunSci AdvJACSAdv Materȹ֪־SCI80ƪѡΨ(Clarivate Analytics)2019ȫ򡰸߱ѧҡ񵥡αȫУ滮̲4Ӣר12ùרȨ72ҵתƼٴת

Email: gangliu.cmitm@xmu.edu.cn
ҳ: 
https://mitm.xmu.edu.cn/info/1012/1228.htm
׫壺ԭ
༭΢챨༭

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